Response to House Dust Mites is Age-Dependent

Neuherberg, August 2016: Adults suffering from a house dust mite allergy, exhibit a cascade of inflammatory signals on the surface of their airways, which leads to airway remodeling. This process cannot be influenced by standard cortisone therapy. In an experimental model researchers around Dr. Julia Esser-von Bieren (research group Immunemodulation) have reported that Wnt5a, the enzymes transglutaminase 2 and phospholipase A2 as well as leukotrienes are involved in this process. These findings were published in the latest issue of the ‘Journal of Allergy and Clinical Immunology’.

Age dictates a steroid resistant cascade of Wnt5a, transglutaminase-2 and leukotrienes in inflamed airways. DOI:10.1016/j.jaci.2016.07.014, Original Publication

 

Source: Helmholtz Zentrum München

Head

Prof. Dr. rer. nat. Carsten B. Schmidt-Weber
Chair for Molecular Allergology (Klinikum rechts der Isar)
Director of the Institute of Allergy research (IAF; Helmholtz Zentrum München)

Contact

Zentrum Allergie und Umwelt (ZAUM) 
Technische Universität und Helmholtz Zentrum München
Libuse Pilz (Sekretariat)

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Germany

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