Publications

2018

Ogawa, C., Bankoti, R., Nguyen, T., Hassanzadeh-Kiabi, N., Nadeau, S., Porritt, R., Couse, M., Fan, X., Dhall, D., Eberl, G., Ohnmacht, C. and G. Martins. Blimp1 functions as a molecular switch to prevent production of inflammatroy cytokines and loss of  suppressor activity in RORγt+Foxp3+ Treg cells. 

Cell reports, in press

 

2017

Barthels, C.#, Ogrinc, A.#, Steyer V., Meier, S., Simon, F., Wimmer, M., Blutke, A., Straub, T., Zimber-Strobl, U., Lutgens, E., Marconi, P., Ohnmacht, C., Garzetti., D., Stecher, B. and Brocker, T. CD40-signaling abrogates induction of ROR?t+ Treg cells by intestinal CD103+ DCs and causes fatal colitis. 

Nature communications 2017, in press

 

2016

Kepert, I., Fonseca, J., Mu?ller, C., Milger, K., Hochwind, K., Kostric, M., Fedoseeva, M., Ohnmacht, C., Dehmel, S., Nathan, P., Bartel, S., Eickelberg, O., Schloter, M., Hartmann, A., Schmitt- Kopplin, P., Krauss-Etschmann, S. D-Tryptophan from probiotic bacteria influences the gut microbiome and allergic airway disease.
Journal of Allergy and Clinical Immunology, doi 10.1016/j.jaci.2016.09.003, in press

Fedoseeva, M. & Ohnmacht, C. Wie die Darmflora Allergien verhindern kann.
Dtsch. Aertzteblatt. 2016, DOI: 10.3238/PersPneumo.2016.06.17.06

Ohnmacht, C. Microbiota, regulatory T cell subsets and allergic disorders.
Allergo J Int. 2016; 25(5):114-123

Ohnmacht, C. Tolerance to The Intestinal Microbiota Mediated by ROR(γt)+ Cells.
Trends Immunol. 2016 Jul;37(7):477-86.

 

2015
Ohnmacht, C.#, Park, J.H.#, Cording, S., Wing, J.B., Atarashi, K., Obata, Y., Gaboriau-Routhiau, V., Marques, R., Dulauroy, S., Fedoseeva, M., Busslinger, M., Cerf-Bensussan, N., Boneca, I.G., Voehringer, D., Hase, K., Honda, K., Sakaguchi, S. and G. Eberl. MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through RORgammat(+) T cells.
Science 349, 989-993.

Wimmer, M.#, Alessandrini, F.#, Gilles, S., Frank, U., Oeder, S., Hauser, M., Ring, J., Ferreira, F., Ernst, D., Winkler, JB., Schmitt-Kopplin, P., Ohnmacht, C., Behrendt, H., Schmidt-Weber, C., Traidl-Hoffmann, C.*, Gutermuth, J*. Pollen-derived nonallergenic substances enhance Th2-induced IgE production in B cells.
Allergy 70, 944-54


2014
Massot, B., Michel, M.L., Diem, S., Ohnmacht, C., Latour, S., Dy, M., Eberl, G., and Leite-de-Moraes, M.C. (2014). TLR-induced cytokines promote effective proinflammatory natural Th17 cell responses.
J Immunol 192, 5635-5642.


2012
Cherrier, M.#, Ohnmacht, C.#, Cording, S.#, and Eberl, G. (2012). Development and function of intestinal innate lymphoid cells.
Curr Opin Immunol 24, 277-283.


2011
Lochner, M., Ohnmacht, C., Presley, L., Bruhns, P., Si-Tahar, M., Sawa, S., and Eberl, G. (2011). Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells.
J Exp Med 208, 125-134.

Ohnmacht, C.#, Marques, R.#, Presley, L.#, Sawa, S.#, Lochner, M.#, and Eberl, G. (2011). Intestinal microbiota, evolution of the immune system and the bad reputation of pro-inflammatory immunity.
Cell Microbiol 13, 653-659.


2010
Ohnmacht, C.#, Schwartz, C.#, Panzer, M., Schiedewitz, I., Naumann, R., and Voehringer, D. (2010). Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths.
Immunity 33, 364-374.

Ohnmacht, C., and Voehringer, D. (2010). Basophils protect against reinfection with hookworms independently of mast cells and memory Th2 cells.
J Immunol 184, 344-350.


2009
Ohnmacht, C., Pullner, A., King, S.B., Drexler, I., Meier, S., Brocker, T., and Voehringer, D. (2009). Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity.
J Exp Med 206, 549-559.

Ohnmacht, C., and Voehringer, D. (2009). Basophil effector function and homeostasis during helminth infection.
Blood 113, 2816-2825.


2008
King, SB., Knorn, AM., Ohnmacht C. and D. Voehringer. Accumulation of effector CD4 T cells during type 2 immune responses is negatively regulated by Stat6.
J Immunol 2008 180:754-63.


2007
Ohnmacht, C., Pullner, A., van Rooijen, N., and Voehringer, D. (2007). Analysis of eosinophil turnover in vivo reveals their active recruitment to and prolonged survival in the peritoneal cavity.
J Immunol 179, 4766-4774.

# contributed equally as first author.
* contributed equally as last author.

Contact

PD Dr. rer. nat. Caspar Ohnmacht

Zentrum Allergie und Umwelt (ZAUM)
Technische Universität und Helmholtz Zentrum München

Ingolstädter Landstraße 1
85764 Neuherberg

Phone: +49 89 3187-2556
Email:

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