Review on "Tolerance to the Intestinal Microbiota Mediated by ROR(yt)+ cells"

Neuherberg, May 2016: Harmless microbes colonizing the gut require the establishment of a well-equilibrated symbiosis between this microbiota and its host. A recent review summarizes novel insights into how this microbiota is tolerized by the immune system.

 

Particularly, cells expressing the transcription factor RAR-related orphan-like γt [ROR(γt)] seem to control such tolerogenic mechanisms in both the innate and adaptive immune system.