RelB Deficiency in Dendritic Cells Protects from Autoimmune Inflammation Due to Spontaneous Accumulation of Tissue T Regulatory Cells.

Andreas N, Potthast M, Geiselhöringer AL, Garg G, de Jong R, Riewaldt J, Russkamp D, Riemann M, Girard JP, Blank S, Kretschmer K, Schmidt-Weber C, Korn T, Weih F, Ohnmacht C.

J Immunol. 2019 in press


Dendritic Cell Accumulation in the Gut and Central Nervous System Is Differentially Dependent on α4 Integrins.

Sie C, Perez LG, Kreutzfeldt M, Potthast M, Ohnmacht C, Merkler D, Huber S, Krug A, Korn T.

J Immunol. 2019 Sep 15;203(6):1417-1427.


Aire-expressing ILC3-like cells in the lymph node display potent APC features.
Yamano T, Dobeš J, Vobořil M, Steinert M, Brabec T, Ziętara N, Dobešová M, Ohnmacht C, Laan M, Peterson P, Benes V, Sedláček R, Hanayama R, Kolář M, Klein L, Filipp D.

Journal of Experimental Medicine 2019 doi: 10.1084/jem.20181430


IL-4 receptor α blockade prevents sensitization and alters acute and long-lasting effects of allergen-specific immunotherapy of murine allergic asthma.
Russkamp D, Aguilar-Pimentel A, Alessandrini F, Gailus-Durner V, Fuchs H, Ohnmacht C, Chaker A, de Angelis MH, Ollert M, Schmidt-Weber CB, Blank S.

Allergy 2019 doi: 10.1111/all.13759


Hematopoietic ChemR23 (Chemerin Receptor 23) Fuels Atherosclerosis by Sustaining an M1 Macrophage-Phenotype and Guidance of Plasmacytoid Dendritic Cells to Murine Lesions.
Van der Vorst EPC, Mandl M, Müller M, Neideck C, Jansen Y, Hristov M, Gencer S, Peters LJF, Meiler S, Feld M, Geiselhöringer AL, de Jong RJ, Ohnmacht C, Noels H, Soehnlein O, Drechsler M, Weber C, Döring Y.

Arterioscler Thromb Vasc Biol. 2019 doi: 10.1161/ATVBAHA.119.312386. [Epub ahead of print]


Defining Dysbiosis in Inflammatory Bowel Disease.
de Jong, R. and C. Ohnmacht. 

Immunity 2019, 50(1): 8-10



Ogawa, C., Bankoti, R., Nguyen, T., Hassanzadeh-Kiabi, N., Nadeau, S., Porritt, R., Couse, M., Fan, X., Dhall, D., Eberl, G., Ohnmacht, C. and G. Martins. Blimp1 functions as a molecular switch to prevent production of inflammatroy cytokines and loss of  suppressor activity in RORγt+Foxp3+ Treg cells. 

Cell reports, in press



Barthels, C.#, Ogrinc, A.#, Steyer V., Meier, S., Simon, F., Wimmer, M., Blutke, A., Straub, T., Zimber-Strobl, U., Lutgens, E., Marconi, P., Ohnmacht, C., Garzetti., D., Stecher, B. and Brocker, T. CD40-signaling abrogates induction of ROR?t+ Treg cells by intestinal CD103+ DCs and causes fatal colitis. 

Nature communications 2017, in press



Kepert, I., Fonseca, J., Mu?ller, C., Milger, K., Hochwind, K., Kostric, M., Fedoseeva, M., Ohnmacht, C., Dehmel, S., Nathan, P., Bartel, S., Eickelberg, O., Schloter, M., Hartmann, A., Schmitt- Kopplin, P., Krauss-Etschmann, S. D-Tryptophan from probiotic bacteria influences the gut microbiome and allergic airway disease.
Journal of Allergy and Clinical Immunology, doi 10.1016/j.jaci.2016.09.003, in press

Fedoseeva, M. & Ohnmacht, C. Wie die Darmflora Allergien verhindern kann.
Dtsch. Aertzteblatt. 2016, DOI: 10.3238/PersPneumo.2016.06.17.06

Ohnmacht, C. Microbiota, regulatory T cell subsets and allergic disorders.
Allergo J Int. 2016; 25(5):114-123

Ohnmacht, C. Tolerance to The Intestinal Microbiota Mediated by ROR(γt)+ Cells.
Trends Immunol. 2016 Jul;37(7):477-86.


Ohnmacht, C.#, Park, J.H.#, Cording, S., Wing, J.B., Atarashi, K., Obata, Y., Gaboriau-Routhiau, V., Marques, R., Dulauroy, S., Fedoseeva, M., Busslinger, M., Cerf-Bensussan, N., Boneca, I.G., Voehringer, D., Hase, K., Honda, K., Sakaguchi, S. and G. Eberl. MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through RORgammat(+) T cells.
Science 349, 989-993.

Wimmer, M.#, Alessandrini, F.#, Gilles, S., Frank, U., Oeder, S., Hauser, M., Ring, J., Ferreira, F., Ernst, D., Winkler, JB., Schmitt-Kopplin, P., Ohnmacht, C., Behrendt, H., Schmidt-Weber, C., Traidl-Hoffmann, C.*, Gutermuth, J*. Pollen-derived nonallergenic substances enhance Th2-induced IgE production in B cells.
Allergy 70, 944-54

Massot, B., Michel, M.L., Diem, S., Ohnmacht, C., Latour, S., Dy, M., Eberl, G., and Leite-de-Moraes, M.C. (2014). TLR-induced cytokines promote effective proinflammatory natural Th17 cell responses.
J Immunol 192, 5635-5642.

Cherrier, M.#, Ohnmacht, C.#, Cording, S.#, and Eberl, G. (2012). Development and function of intestinal innate lymphoid cells.
Curr Opin Immunol 24, 277-283.

Lochner, M., Ohnmacht, C., Presley, L., Bruhns, P., Si-Tahar, M., Sawa, S., and Eberl, G. (2011). Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells.
J Exp Med 208, 125-134.

Ohnmacht, C.#, Marques, R.#, Presley, L.#, Sawa, S.#, Lochner, M.#, and Eberl, G. (2011). Intestinal microbiota, evolution of the immune system and the bad reputation of pro-inflammatory immunity.
Cell Microbiol 13, 653-659.

Ohnmacht, C.#, Schwartz, C.#, Panzer, M., Schiedewitz, I., Naumann, R., and Voehringer, D. (2010). Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths.
Immunity 33, 364-374.

Ohnmacht, C., and Voehringer, D. (2010). Basophils protect against reinfection with hookworms independently of mast cells and memory Th2 cells.
J Immunol 184, 344-350.

Ohnmacht, C., Pullner, A., King, S.B., Drexler, I., Meier, S., Brocker, T., and Voehringer, D. (2009). Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity.
J Exp Med 206, 549-559.

Ohnmacht, C., and Voehringer, D. (2009). Basophil effector function and homeostasis during helminth infection.
Blood 113, 2816-2825.

King, SB., Knorn, AM., Ohnmacht C. and D. Voehringer. Accumulation of effector CD4 T cells during type 2 immune responses is negatively regulated by Stat6.
J Immunol 2008 180:754-63.

Ohnmacht, C., Pullner, A., van Rooijen, N., and Voehringer, D. (2007). Analysis of eosinophil turnover in vivo reveals their active recruitment to and prolonged survival in the peritoneal cavity.
J Immunol 179, 4766-4774.

# contributed equally as first author.
* contributed equally as last author.


PD Dr. rer. nat. Caspar Ohnmacht

Zentrum Allergie und Umwelt (ZAUM)
Technische Universität und Helmholtz Zentrum München

Ingolstädter Landstraße 1
85764 Neuherberg

Phone: +49 89 3187-2556

We use cookies to improve your experience on our Website. We need cookies to continually improve our services, enable certain features, and when we embed third-party services or content, such as the Vimeo video player or Twitter feeds. In such cases, information may also be transferred to third parties. By using our website, you agree to the use of cookies. We use different types of cookies. You can personalize your cookie settings here:

Show detail settings
Please find more information in our privacy statement.

There you may also change your settings later.